Gata1 transcription factor
WebThe GATA1 protein is also important for the maturation of several types of white blood cells that help fight infection, including eosinophils, mast cells, and dendritic cells. Two … WebOct 30, 2024 · (A and B) rs10892563 is located at a binding site of erythroid-specific transcription factor GATA1. Dual luciferase assay with the vector inserted with a stretch of sequence with the motif revealed that C allele of rs10892563 down-regulated GATA1 cis-transcriptional function compared to the major allele T in 293T cells; P=0.0038. (C and …
Gata1 transcription factor
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WebA GATA-1 knockdown model, the GATA1-1.05/X female mice, is characterized by peripheral cytopenias, accumula- ... Transcription factor GATA-1 permits survival and matu-ration … WebApr 13, 2024 · The GATA transcription factor family Mammalian genomes encode six structurally related members of the GATA family, which function as tissue-specific master …
WebGATA transcription factors are required for the differentiation of diverse cell types in several species. Recent evidence suggests that their biologic activities may be modulated through interaction with multitype zinc finger proteins, such as Friend of GATA-1 (FOG) and U-shaped (Ush). In cell culture, FOG cooperates with the hematopoietic ... WebJan 20, 2024 · Papadopoulos, P. et al. TAF10 interacts with the GATA1 transcription factor and controls mouse erythropoiesis. Mol. Cell. Biol. 35, 2103–2118 (2015).
Webnote that the transcription factor NF-Y binding to the CCAAT site within the Gfi-1B promoter plays a critical role in GATA-1 responsiveness. In summary, we have … WebThe novel GATA1-interacting protein HES6 is an essential transcriptional cofactor for human erythropoiesis. Normal erythropoiesis requires the precise regulation of gene …
WebNov 25, 2024 · Abstract. GATA1 is considered as the “master” transcription factor in erythropoiesis. It regulates at the transcriptional level all aspects of erythroid maturation and function, as revealed by gene …
WebGATA1, a zinc finger transcription factor that drives erythroid gene expression, is essential for erythroid cell maturation (Pevny et al., 1991). Surprisingly, mouse embryos lacking … photo lester holt wifeWebJun 14, 2024 · The GATA1 gene encodes a zinc finger DNA-binding transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. The … how does history help usWebGATA1 is expressed in primitive and definitive erythroid cells (27, 55), megakaryocytes (61, 92), eosinophils (138), and mast cells (61) and in the Sertoli cells of the testis … how does history impact our societyWebGATA transcription factor s are a family of transcription factors characterized by their ability to bind to the DNA sequence "GATA". [1] GATA transcription factors have been correlated to their broader influence on stem cell development. Findings however, have pointed to a more direct influence by GATA transcription factors, as they are salient ... photo lens testing gridWebThe GATA family of transcription factors is comprised of six members characterized by their binding to the consensus DNA sequence (T/A)GATA(A/G). GATA1, which was the initially described member of the GATA family, is predominantly expressed in cells of the myeloid lineage such as erythrocytes, eosinophils, mast cells, and megacaryocytes. photo lens in fresno caWebApr 13, 2024 · The discovery of the GATA binding protein (GATA factor) transcription factor family revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our understanding of how hematopoietic stem and progenitor cells develop from precursors, how progenitors generate red blood cells, how hemoglobin synthesis is … photo letchisWebAug 1, 2012 · GATA binding protein 1 (GATA1, GenBank ID: NM_002049) is a key haematopoietic transcription factor with a pivotal role in differentiation of the erythroid, megakaryocyte, eosinophil and mast cell lineages[].The GATA1 gene produces at least two protein isoforms—the well characterised GATA1 full-length (GATA1FL) isoform and a … how does history inform and inspire us