WebGrowth arrest-specific gene 6 transfer promotes mesenchymal stem cell survival and cardiac repair under hypoxia and ischemia via enhanced autocrine signaling and paracrine action; the Gas6/Axl interaction was inhibited by R428, which abolished the preventive effect of VK2 on CaCl2- and beta-GP-induced apoptosis and calcification. These results ... Webpointed to a secreted protein called growth arrest-specific 6 (GAS6) as a candidate molec - ular messenger. Indeed, delivering GAS6 into the skin using an adenovirus vector (a com-mon tool in gene therapy) not only stimulated hair growth in normal mice, but also restored hair growth during chronic stress or cortico-sterone feeding.
GAS6 is a key homeostatic immunological regulator of host ... - PNAS
WebNov 16, 2024 · Growth arrest-specific gene 6 protein (Gas6) is avitamin K-dependent tissue bound protein. Gas6 has been shown to promote growth and therapy resistance among different types of cancer as well as thromboembolism. The aim of this prospective screening study: ClinicalTrials.gov; Identifier: NTC3782025, was to evaluate the effects … WebAim: Gas6 is known to be elevated in sepsis, correlating with the severity of infection and organ failure. We aimed to investigate the performance of Gas6 plasma levels at admission to predict the risk of mortality in a cohort of septic how to use diaphragm turkey calls
Gas6 expression is reduced in advanced breast cancers
WebConversely, under chronic stress, increased levels of corticosterone prolong HFSC quiescence and maintain hair follicles in an extended resting phase. Mechanistically, … WebMar 9, 2024 · The growth-arrest specific 6 (GAS6) protein has emerged in recent years as an attractive target for drug development primarily because it is the sole ligand for the AXL receptor tyrosine kinase, which plays critical roles in cancer, fibrosis, and viral infection. WebGrowth arrest specific 6 (GAS6) encodes a protein that serves as a ligand for AXL receptor tyrosine kinase and stimulates cell proliferation. Notably, an antisense RNA, namely GAS6-AS1 is transcribed from chromosome 13q34, near GAS6 gene. In vitro functional experiments have demonstrated that GAS6-A … how to use diaper changing mat