Web29 jun. 2024 · Here, we show that hepatic vagotomy decreases 1-week cumulative light cycle food intake by 22% in diet-induced obese mice, resulting in a 5.3% decrease in cumulative 24-h food intake (Figure S8A). We continued daily food intake measurements for the next 2 weeks as all mice were treated with the GABA-T-targeted ASO. Web29 jun. 2024 · Hepatic vagotomy lowers serum insulin, improves glucose tolerance, and improves insulin sensitivity, recapitulating the response to GABA-T ASO-mediated knockdown or GABA-T pharmacological inhibition. This further supports our hypothesis that an obesity-induced increase in hepatic GABA production relies upon the HVAN to …
GLP-1 release and vagal afferent activation mediate the ... - Nature
Web7 jun. 2016 · In rats, liver regeneration after partial hepatectomy was impaired following vagotomy, implicating important role of the parasympathetic nervous system. 55 Furthermore, inhibition of the … WebThe hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia Diabetic rats both overeat high-carbohydrate diet and have altered hypothalamic neuropeptide Y (NPY) and corticotropin-releasing factor (CRF). In contrast, a high-fat diet reduces caloric intake of diabetics to normal, reflected by normal hypothalamic NPY and CRF content. iad to tus flights
Impact of the Hepatic Branch of the Vagus Nerve Transection
Web23 aug. 2004 · Also, hepatic branch vagotomy not only eliminates vagal fibers since it was estimated that up to 30% of the nerve fibers running in this branch are of nonvagal origin (Prechtl and Powley, 1990 ). WebHepatic Vagotomy Increased Fas-Induced Apoptosis in the Liver As shown in Figure 2A, after treatment with a high dose of Jo-2, all of the vagotomized mice became lethargic and died rapidly, although 2 of 10 of the sham-operated mice (20%) survived (P.05). WebVagotomy+Cirrhosis groups showed higher hepatic steatosis due to higher SREBP1 and low Insig2 protein and altered activation of key genes involved in hepatic lipid … iad toucy