Web1 jun. 2014 · N-myc belongs to the Myc family of proto-oncogenes, which are transcription factors of the basic-helix–loop–helix–zipper (bHLHZ) class and important for the regulation of gene expression associated with a range of cellular processes, including proliferation, growth, apoptosis, energy metabolism, and differentiation ().Other Myc family … Web4 mrt. 2024 · Synthetic lethal screening, which exploits the combination of mutations that result in cell death, is a promising method for identifying novel drug targets. This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc. Here, we revisit current methods used to target c-Myc and discuss the important functional nodes related …
(PDF) Splicing and Dicing MYC-Mediated Synthetic Lethality
Web89 NMTi is synthetic lethal in high-MYC cancers . 90 To test the hypothesis that MYC deregulation is synthetic lethal with NMTi, we determined the . 91 sensitivity of P493-6 immortalized B cells carrying tetracycline-inducible MYC expression (21) to . 92 IMP1088 (Fig. 1B, Supplementary Fig. 5A), an NMTi with high potency against a panel of ... jeremiah lighting winton
Splice‐switch oligonucleotide‐based combinatorial platform …
WebOverexpressed Myc primes cells to the lethal effect of VX-680 by promoting illegal DNA synthesis and mitosis in the absence of cytokinesis [4,6]. This Myc activity allows pulsed treatments with VX-680 to achieve an enduring anticancer effect by eliciting delayed lethality without the requirement of continuous exposure to the drug. Web24 mrt. 2024 · Here, we conducted a high-content screen for compounds that are synthetic lethal to elevated MYC using a small-molecule library to identify compounds that are closely related to, or are themselves, regulatory-approved drugs. The screen identified dimethylfasudil, a potent and reversible inhibitor of Rho-associated kinases, ROCK1 and … WebMYC is a basic helix-loop-helix zipper (bHLHZ) motif–containing transcription factor whose activity is tightly regulated by its direct binding to another bHLHZ protein MAX. MYC … jeremiah lasky saved by the bell