WebTransferrin Receptor Protein-1 (TFRC) is a cell surface receptor that binds ferric-iron-loaded transferrin in the bloodstream at high affinity to facilitate iron uptake into cells. TFRC is therefore an integral component of the body’s iron supply chain and general homeostasis. Web23 Jan 2024 · To obtain TFRC knockdown cells, short hairpin RNA (shRNA) transfection method was used to transfect it into HeLa cells. The TFRC -shRNA sequence (5ʹ-GCT GGT CAG TTC GTG ATT AAA-3ʹ) was introduced into pGFP-B-RS vectors (Origene, Peking, China), which were digested by BamH I and Hind III enzymes.
Frontiers Antibodies Targeting the Transferrin Receptor 1 (TfR1) …
Web19 May 2024 · MYCN is a regulator of GPX4-dependent ferroptosis. To study MYCN-dependent cellular processes in NB, we examined a collection of 147 genes essential for the survival of MYCN-amplified NB cells 17 ... WebTFRC INFORMATION. Proteini. Full gene name according to HGNC. Transferrin receptor. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. TFRC (CD71, p90, TFR1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). ego snc udine
TFRC transferrin receptor [Homo sapiens (human)] - Gene - NCBI
Web3 May 2024 · TfRC was accumulated after the inhibition of autophagy by treatment with autophagic inhibitor chloroquine or knockdown of ATG2A. The intracellular iron content was increased in cells overexpressing TfRC or mutant WDR45, however, ferritin H (FTH) chain was decreased. WebTransferrin receptor 1. Transferrin receptor protein 1 ( TfR1 ), also known as C luster of D ifferentiation 71 ( CD71 ), is a protein that in humans is encoded by the TFRC gene. [5] [6] … Web11 Jul 2024 · TFRC encodes the transferrin receptor protein 1 (TFR1, UniProt-P02786) in human, which controls the level of intracellular iron levels. TFR1 imports iron from the … te akau stud