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Tfrc knockin

WebTransferrin Receptor Protein-1 (TFRC) is a cell surface receptor that binds ferric-iron-loaded transferrin in the bloodstream at high affinity to facilitate iron uptake into cells. TFRC is therefore an integral component of the body’s iron supply chain and general homeostasis. Web23 Jan 2024 · To obtain TFRC knockdown cells, short hairpin RNA (shRNA) transfection method was used to transfect it into HeLa cells. The TFRC -shRNA sequence (5ʹ-GCT GGT CAG TTC GTG ATT AAA-3ʹ) was introduced into pGFP-B-RS vectors (Origene, Peking, China), which were digested by BamH I and Hind III enzymes.

Frontiers Antibodies Targeting the Transferrin Receptor 1 (TfR1) …

Web19 May 2024 · MYCN is a regulator of GPX4-dependent ferroptosis. To study MYCN-dependent cellular processes in NB, we examined a collection of 147 genes essential for the survival of MYCN-amplified NB cells 17 ... WebTFRC INFORMATION. Proteini. Full gene name according to HGNC. Transferrin receptor. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. TFRC (CD71, p90, TFR1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). ego snc udine https://bassfamilyfarms.com

TFRC transferrin receptor [Homo sapiens (human)] - Gene - NCBI

Web3 May 2024 · TfRC was accumulated after the inhibition of autophagy by treatment with autophagic inhibitor chloroquine or knockdown of ATG2A. The intracellular iron content was increased in cells overexpressing TfRC or mutant WDR45, however, ferritin H (FTH) chain was decreased. WebTransferrin receptor 1. Transferrin receptor protein 1 ( TfR1 ), also known as C luster of D ifferentiation 71 ( CD71 ), is a protein that in humans is encoded by the TFRC gene. [5] [6] … Web11 Jul 2024 · TFRC encodes the transferrin receptor protein 1 (TFR1, UniProt-P02786) in human, which controls the level of intracellular iron levels. TFR1 imports iron from the … te akau stud

Transferrin receptor‐mediated iron uptake is essential for colon …

Category:Iron metabolism protein transferrin receptor 1 involves in cervical

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Tfrc knockin

Transferrin receptor 1 controls systemic iron homeostasis by fine ...

Web15 Aug 2014 · The assay location is chr.16:32626732 on NCBI build 37. It has a 91 bp amplicon that maps within exon 17 of the Tfrc gene. TaqMan™ Copy Number Reference Assay, Mouse, Tert is an alternative reference assay; it is recommended in the event that the Tfrc assay functions poorly with a sample because of chromosomal aberrations or other … Web24 Jan 2024 · Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types. Its critical physiological function is …

Tfrc knockin

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Web17 Jan 2024 · Transferrin receptor (TFRC), which was overexpressed in cervical cancer and involved in the HIF-1 pathway, was associated with advanced clinical pathologic …

WebFig. 1. The central biochemical event of ferroptotic cancer cell death. The central biochemical event of ferroptosis is involved in iron accumulation and lipid peroxidation, which leads to oxidative injury and cell death. ROS, reactive oxygen species. Iron is an important trace element in many species. WebTFRC CRISPR Knock Out Line. Technique. CV40 transformed cell line or 293tsA1609neo from human kidney 293 cells delivered as 1. Species. Human, Humans. Alternative name. …

WebTFRC Knockout Cell Line-HeLa Cat.No. CSC-RT1891 Description HeLa -TFRC (-/-) is a stable cell line with a homozygous knockout of human TFRC using CRISPR/Cas9. Host Cell HeLa Shipping 1 vial of knockout cell line and 1 vial of wildtype cell line Storage Liquid nitrogen Gene Information Gene Name TFRC Gene Symbol TFRC Gene ID 7037 Q&A Web27 Oct 2024 · Results presented Fig. 5c demonstrate that TFR1 (CD71) and iron regulatory protein 1 (IRP1) are downregulated in the presence of HSA-heme in Jurkat T cells, …

Web16 Apr 2024 · The TFRC-sh, TFRC-OE, SLC7A11-sh, and SLC7A11-OE plasmids were purchased from GeneChem (Shanghai, China). The plasmids with truncated TFRC promoter regions that were cloned into pGL3 were ...

Web6 Sep 2024 · The TFRC gene encodes the transferrin receptor, which is important for cellular iron uptake. Circulating apotransferrin (TF; 190000) binds 2 Fe (3+) ions to form holotransferrin, which binds to TFRC. The TFRC-holotransferrin complex is internalized by receptor-mediated endocytosis (summary by Jabara et al., 2016 ). te akau stud limitedWeb8 Jun 2024 · Background and Aims: Iron deficiency (ID) is a frequent extra-intestinal manifestation in patients with Inflammatory Bowel Disease (IBD), who often do not respond to iron supplementation. Iron is a cofactor for hydroxylases that suppress the hypoxia-inducible factor-1α (HIF1α), a transcription factor regulating iron homeostasis. We … te ako o te tuiWebTransferrin Receptor Protein-1 (TFRC) is a cell surface receptor that binds ferric-iron-loaded transferrin in the bloodstream at high affinity to facilitate iron uptake into cells. TFRC is … te akau stud newsWeb2 May 2024 · The TfR-mediated incorporation of JR-141 was confirmed by using human fibroblasts in vitro. When administrated intravenously to hTfR knockin mice or monkeys, … ego stanjaWebA “transferrin binding site” as used herein refers to regions in the helical and protease-like domain of a TfR protein that mediate binding of transferrin, e.g., iron-bound transferrin, to … te akau stud ownerWeb5 Jul 2024 · The Tfrc AKO mice were also protected from obesity induced by a high-fat diet (HFD). Compared with control mice, Tfrc AKO mice had increased iron storage in the liver and a lower adipose mass ... ego studio moravanyWeb2 May 2024 · The TfR-mediated incorporation of JR-141 was confirmed by using human fibroblasts in vitro. When administrated intravenously to hTfR knockin mice or monkeys, … te akshar per ladkon ke naam